. The results indicate that advanced paternal age at conception has negative long-term effects on reproductive fitness and longevity of offspring in

the mouse model.


Delayed fatherhood in mice decreases reproductive fitness
and longevity of offspring1
Short title: Long-term effects of paternal age on offspring
Summary sentence: Delayed fatherhood decreases reproductive fitness and longevity of
offspring in the mouse model
Key words: delayed fatherhood long-term effects offspring
Silvia García-Palomares3, Samuel Navarro4, José F. Pertusa3, Carlos Hermenegildo5,6,
Miguel A. García-Pérez5,7, Francisco Rausell3, Antonio Cano8 and Juan J. Tarín2,3
1Supported by grant BFI2003-04761 from “Ministerio de Ciencia y Tecnología”, cofinanced by
the “Fondo Europeo de Desarrollo Regional (FEDER); grant ISCIII2006-PI0405 from “Instituto
de Salud Carlos III, Fondo de Investigación Sanitaria, Ministerio de Sanidad y Consumo”,
cofinanced by the FEDER; and grants GV2004-B-206 and AE/2007/001 from “Generalitat
Valenciana, Conselleria d’Émpresa, Universitat i Ciencia”.
2Correspondence: Juan J. Tarín, Department of Functional Biology and Physical Anthropology,
Faculty of Biological Sciences, University of Valencia, Dr. Moliner 50, 46100 Burjassot,
Valencia, Spain; Tel. 34-96-354 3221; E-mail: tarinjj@uv.es
3Department of Functional Biology and Physical Anthropology, Faculty of Biological Sciences,
University of Valencia, Burjassot, 46100 Valencia, Spain
4Department of Pathology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain
5Research Unit, Hospital Clínico de Valencia, 46010 Valencia, Spain
BOR Papers in Press. Published on October 15, 2008 as DOI:10.1095/biolreprod.108.073395
Copyright 2008



1: Biol Reprod. 2008 Oct 15. [Epub ahead of print]
Links
Delayed Fatherhood in Mice Decreases Reproductive Fitness and Longevity of Offspring.
García-Palomares S, Navarro S, Pertusa JF, Hermenegildo C, García-Pérez MA, Rausell F, Cano A, Tarín JJ.
This study aims to analyze, in mice, the long-term effects of delayed fatherhood on reproductive fitness and longevity of offspring. Hybrid parental-generation (F0) males, at the age of 12, 70, 100, and 120 weeks, were individually housed with a randomly-selected 12 week-old hybrid female. The reproductive fitness of first-generation (F1) females was tested from the age of 25 weeks until the end of their reproductive life. In F1 males, the testing period ranged from the age of 52 weeks until death. Breeding F1 females from the 120-week group displayed interbirth intervals longer than females from the 12-, 70- and 100-week groups. Furthermore, F2 pups begotten by F1 studs exhibited weaning weights lower than pups from the 12- and 70-week groups. Offspring from the 120-week group exhibited shorter survival times associated with lower incidence of tumorigenesis and higher loss of body weight when approaching death when compared to F1 offspring from younger age groups. The results indicate that advanced paternal age at conception has negative long-term effects on reproductive fitness and longevity of offspring in the mouse model.
PMID: 18923156 [PubMed - as supplied by publisher]