Older Fathers do not produce Healthy Offspring on a Population Level

Long-term effects of delayed fatherhood in mice on postnatal
development and behavioral traits of offspring1
Short title: Long-term effects of paternal age on offspring
Summary sentence: Delayed fatherhood has long-term effects on preweaning development,
spontaneous motor activity and passive-avoidance learning capacity of offspring in the mouse
model
Key words: delayed fatherhood long-term effects offspring
Silvia García-Palomares3, José F. Pertusa3, José Miñarro4, Miguel A. García-Pérez5,6,
Carlos Hermenegildo5,7, Francisco Rausell3, Antonio Cano8 and Juan J. Tarín2,3
1Supported by grant BFI2003-04761 from “Ministerio de Ciencia y Tecnología”, cofinanced by
the “Fondo Europeo de Desarrollo Regional (FEDER); grant ISCIII2006-PI0405 from “Instituto
de Salud Carlos III, Fondo de Investigación Sanitaria, Ministerio de Sanidad y Consumo”,
cofinanced by the FEDER; and grants GV2004-B-206 and AE/2007/001 from “Generalitat
Valenciana, Conselleria d’Émpresa, Universitat i Ciencia”.
2Correspondence: Juan J. Tarín, Department of Functional Biology and Physical Anthropology,
Faculty of Biological Sciences, University of Valencia, Dr. Moliner 50, 46100 Burjassot,
Valencia, Spain; Tel. 34-96-354 3221; E-mail: tarinjj@uv.es
3Department of Functional Biology and Physical Anthropology, Faculty of Biological Sciences,
University of Valencia, Burjassot, 46100 Valencia, Spain
BOR







Biol Reprod. 2008 Oct 15. [Epub ahead of print] Links
Long-Term Effects of Delayed Fatherhood in Mice on Postnatal Development and Behavioral Traits of Offspring.García-Palomares S, Pertusa JF, Miñarro J, García-Pérez MA, Hermenegildo C, Rausell F, Cano A, Tarín JJ.
This study aims to analyze, in mice, the long-term effects of delayed fatherhood on postnatal development, spontaneous motor activity and learning capacity of offspring. Hybrid parental-generation (F0) males, at the age of 12, 70, 100, and 120 weeks, were individually housed with a randomly-selected 12 week-old hybrid female. The resulting first-generation (F1) offspring were tested for several developmental and behavioral variables. Cumulative percentage of F1 pups that attained immediate righting in the 120-week group was lower than that found in the 12-, 70- and 100-week groups. Furthermore, the postnatal day of attaining immediate righting was higher in pups from the 120-week group when compared to pups from the other age groups. At the age of 20 weeks, F1 offspring from the 120-week group displayed lower counts of motor activity than offspring from the 12-, 70- and 100-week groups. One week later, a higher percentage of offspring from the 100- and 120- groups entered the dark compartment during the retention trial of the passive avoidance test when compared to offspring from the 12-week group. Offspring from the 120-week group exhibited also lower step-through latency in the retention trial than offspring from the 12-, 70- and 100-week groups. These results show that advanced paternal age at conception has long-term effects on preweaning development, spontaneous motor activity and reduced passive-avoidance learning capacity of mouse offspring.

PMID: 18923158 [PubMed - as supplied by publisher]

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