J Pediatr. 1975 Older paternal age and fresh gene mutation: data on additional disorders.
Older paternal age and genetic disorders in offspring an old story that has been suppressed. Older is over 32 and up! 23-30 is the best age to father babies for their health.
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1: J Pediatr. 1975 Jan;86(1):84-8.
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Older paternal age and fresh gene mutation: data on additional disorders.
Jones KL, Smith DW, Harvey MA, Hall BD, Quan L.
Older paternal age has previously been documented as a factor in sporadic fresh mutational cases of several autosomal dominant disorders. In this collaborative study, an older mean paternal age has been documented in sporadic cases of at least five additional dominantly inheritable disorders; the basal cell nevus syndrome, the Waardenburg syndrome, the Crouzon syndrome, the oculo-dental-digital sysdrome, and the Treacher-Collins syndrome. It was also found to be a factor in acrodysostosis and progeria, suggesting a fresh mutant gene etiology for these two conditions in which virtually all cases have been sporadic and the mode of genetic etiology has been unknown.
PMID: 1110452 [PubMed - indexed for MEDLINE]
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