"It is very possible that PATERNAL AGE is the major predictor of(non-familial) autism." Harry Fisch, M.D., author "The Male Biological Clock". Sperm DNA mutates and autism, schizophrenia bipolar etc. results. What is the connection with autoimmune disorders? Having Type 1 diabetes, SLE,etc. in the family, also if mother had older father. NW Cryobank will not accept a sperm donor past 35th BD to minimize genetic abnormalities.VACCINATIONS also cause autism.

Saturday, September 29, 2007

Old Eggs do not cause autism --The Hockey Stick ignores the Medieval Warm Period and the Little Ice Age.

Loads of papers report that increasing paternal age causes new mutations and new genetic disorders in offspring. Ovum do not accumulate spontaneous mutations because they do not divide more than a few times until fertilized. There is a good reason not to ignore this fact. It is not old eggs. It is increasing paternal age causing spontaneous mutations in sperm stem cells and sperm, hundreds and hundreds of divisions take place and genetic DNA errors do accumulate. CO2 emissions are not the cause of global warming; the change is caused by solar activity. This is a natural cycle.

The general public does not know that the hockey stick is inaccurate, CO2 is not the culprite it is painted to be or that a warming period follows a colder period in approximately 1500 year cycles. They don't know that older fathering of babies is risky for the genetic health of the child; that paternal age is a known risk factor for neurocognitive disorders such as what is called "autism" today. The public does not know that the hockey stick is not accurate. There is no public health advisory urging men to father in their 20s and early thirties, even though epidemiologists and some psychiatrists would like the public to know about advancing paternal age past 32 and genetic disorders. Leslie B. Raschka,M.D., Isabelle Bray Ph.D., Philip Gorwood,M.D., Michael Craig Miller, M.D. Why is the information we receive about these matters contrary to the findings in epidemiology and climatology? I don't know. Dolores Malaspina predicts that there will be a greater percentage of offspring with neurocognitive disorders as the demographics of paternal age shifts ever higher. Is the rise in autism really surprising? Not to those who know the science of de novo/spontaneous/germ line mutations.

October 23, 2006
Tropical Seas Sink Hockey Stick
Filed under: Temperature History, Paleo/Proxy
Defending the “Hockey Stick” depiction of hemispheric or global temperature for the past 1,000 years just got a lot tougher. The “Hockey Stick” curiously wipes out the “Medieval Warm Period” of 1,000 years ago and the “Little Ice Age” that began 450 years ago and ended around 1900. We are supposed to look at the blade of the stick and conclude that the warming of the past 100 years is completely unlike anything seen for at least 1,000 years. It comes as no surprise that the “Hockey Stick” is prominently presented in many of the documents of the Intergovernmental Panel on Climate Change (IPCC). Defenders of the “Hockey Stick” make claims that the Medieval Warm Period and Little Ice Age were confined to the mid-to-high latitudes of the Northern Hemisphere and not felt throughout the rest of the world. This always seemed odd to us at World Climate Report given that variations of solar output seem to explain the higher temperatures 1,000 years ago and the colder temperatures of the Little Ice Age......

Mutation Rate: Sex Biases
Standard Article
Laurence D Hurst, University of Bath, Bath, UK
Copyright © 2006 John Wiley & Sons, Ltd. All rights reserved.DOI: 10.1038/npg.els.0006093Article Online Posting Date: January 27, 2006

Abstract Full Text: HTML PDF (76K)

At least in humans, more spontaneous point mutations occur in the male germ line than in the female germ line. One explanation for this is the greater number of germ-cell divisions in males than in females.
Keywords: point mutations; germ-cell divisions; sex chromosomes; methylation; neutral evolution; dominance

Study: Autism linked to genetic mutations, mother's age

"The older the mother, the more likely she has acquired spontaneous mutations" in her chromosomes, and will transmit them at conception, Dr. Wigler said. Less frequently, but just as likely, Dr. Wigler said, fathers can transmit autism traits as well.

Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8380-6.
Related Articles,
The high spontaneous mutation rate: is it a health risk?Crow JF.Genetics Laboratory, University of Wisconsin, Madison, WI 53706, USA.The human mutation rate for base substitutions is much higher in males than in females and increases with paternal age. This effect is mainly, if not entirely, due to the large number of cell divisions in the male germ line. The mutation-rate increase is considerably greater than expected if the mutation rate were simply proportional to the number of cell divisions. In contrast, those mutations that are small deletions or rearrangements do not show the paternal age effect. The observed increase with the age of the father in the incidence of children with different dominant mutations is variable, presumably the result of different mixtures of base substitutions and deletions. In Drosophila, the rate of mutations causing minor deleterious effects is estimated to be about one new mutation per zygote. Because of a larger number of genes and a much larger amount of DNA, the human rate is presumably higher. Recently, the Drosophila data have been reanalyzed and the mutation-rate estimate questioned, but I believe that the totality of evidence supports the original conclusion. The most reasonable way in which a species can cope with a high mutation rate is by quasi-truncation selection, whereby a number of mutant genes are eliminated by one "genetic death."
"I conclude that for a number of diseases the mutation rate increases with age and at a rate much faster than linear. This suggests that the greatest mutational health hazard in the human population at present is fertile old males. If males reproduced shortly after puberty (or the equivalent result were attained by early collection of sperm and cold storage for later use) the mutation rate could be greatly reduced. (I am not advocating this. For one thing, until many more diseases are studied, the generality of the conclusion is not established. Furthermore, one does not lightly suggest such socially disruptive procedures, even if there were a well-established health benefit.) " 1997 James F. Crow

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