Is the Rise in Neurocognitive Developmental Disorders Unexpected with the Rise in Paternal Age NO!

Not unexpected at all. There has been a 50 year game of blaming the mother's age or some mysterious cause.

What is the role of vaccinations?? What is the connection?

Who is well aware of the paternal age effect?


Why has paternal age risen so much in the last 20 years? Why does the myth that men can father at any age persist when autism, schizophrenia, diabetes, MS, prostate cancer, breast cancer, nervous system cancers, some leukemias, mental retardation, progeria, heart defects, low birth-weight, miscarriages, Down syndrome, epilepsy, kidney disease, fibromyalgia, hemophilia, fragile X, Alzheimer's, etc. etc. all rise in incidence in non-familial/spontaneous/sporadic cases with older paternal age and older maternal grandfather's age? It is also known that women who had fathers over 45 have significantly shorter life spans than those with younger fathers. What happens to the X-chromosome, what happens to the genes that form the brain and nervous system and the immune system? Why do Hispanics have significantly less autism on a population level than Caucasians and Asians in the USA, in California according to the CDC and the other studies? Why has it been known since the 1950s that olders fathers and schizophrenia/autism, etc. are related and the public is steered in late fathering. If you read the many epidemiologic studies or the studies on the increasing DNA breakage in sperm with a man's age you will find the warnings that older paternal age is the most potent cause of genetic disease that seems to come from nowhere. There are many studies that have to do with epidemiology and paternal age and with sperm and older age that are not funded. Why? Why do recent studies on autism not point out the paternal age connection. Even in plants mutations are known to arise predominantly in the paternal germ line, not the maternal germ line.

Who benefits? Who looses? Why are papers warning of the consequences of advanced paternal age (past 31) suppressed and ignored? The rise in "autism" is not unexpected or mysterious!

Journal of Epidemiology and Community Health 2006;60:851-853; doi:10.1136/jech.2005.045179Copyright © 2006 by the BMJ Publishing Group Ltd.


SHORT REPORT
Advanced paternal age: How old is too old? Isabelle Bray, David Gunnell, George Davey Smith
Department of Social Medicine, University of Bristol, UK
Correspondence to:Correspondence to: Dr I Bray Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK; Issy.Bray@bristol.ac.uk

"Average paternal age in the UK is increasing. The public health implications of this trend have not been widely anticipated or debated. This commentary aims to contribute to such a debate. Accumulated chromosomal aberrations and mutations occurring during the maturation of male germ cells are thought to be responsible for the increased risk of certain conditions with older fathers. Growing evidence shows that the offspring of older fathers have reduced fertility and an increased risk of birth defects, some cancers, and schizophrenia. Adverse health outcomes should be weighed up against advantages for children born to older parents, mindful that these societal advantages are likely to change over time."