One Faulty Copy Tips the Balance
Nature Reviews Cancer 7, 725 (October 2007) doi:10.1038/nrc2239
Tumour suppressors: One faulty copy tips the balance
Patrick Goymer
TIP60 is an acetyl-transferase that co-regulates MYC and p53, and modulates the MYC-induced DNA-damage response (DDR). A new study shows that loss of a single copy of Tip60 is associated with tumorigenesis, and that this is caused by impairment of the DDR and is independent of p53
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