Human/male genetic biological clock

When parents are over 35 years old, man and woman alike,
the following cases become prevalent:

Up to a third of all cases of schizophrenia are linked to increasing paternal age.
Men 40 and older are nearly six times more likely to have offspring with autism than men under age 30.
Other research shows that the risk of breast and prostate cancer in offspring increases with paternal age.
The chances of parents of babies with achondroplasia is higher
Older fathers can cause genetic conditions in their offspring, such as birth defects, autism and schizophrenia.
Increased chances of an older woman having a baby with Down's syndrome has been well documented.




Posted by Neriz at Thursday, August 21, 2008
Labels: pasalubong, science

AUTISM SPEAKS SAYS 1CHILD IS DIAGNOSED EVERY 20 MINUTES WITH AUTISM, WE CAN STOP THAT NOW BY OURSELVES

WHY NOT RENAME CHILDHOOD SCHIZOPHRENIA AS AUTISM AND MAKE A FINANCIAL KILLING ON IT AND NEVER TELL THE PUBLIC THAT FATHERING BABIES IN YOUR MID 20s TO VERY EARLY 30s WOULD PREVENT A GREAT DEAL OF PATERNAL AGE AUTISM/CHILDHOOD SCHIZOPHRENIA?

DON'T WALK FOR AUTISM, PASS THE WORD ABOUT THE RIGHT TIME TO FATHER BABIES, AND THE CONNECTION TO A FAMILY HISTORY OF AUTOIMMUNE DISORDERS AND IF THE MOTHER'S FATHER WAS OLDER WHEN SHE WAS BORN
WE CAN LESSEN THE EPIDEMIC AND NOT WASTE OUR MONEY. HAVE THESE CHARITIES STOPPED DUCHENNE'S NO! DIABETES NO! ALL JERRY LEWIS NEEDED TO SAY WAS TO FATHER YOUR BABIES BY 33 AND THERE WOULD BE LESS AUTISM AND DIABETES AND DUCHENNES. SCIENTIFIC RESEARCH ON AUTISM IS A SCAM- AUTISM IS NOT UNKNOWN AND BEFORE 1994 IT WAS A TERM THAT WAS VERY SPECIFIC TO A VERY WELL-DEFINED GROUP OF SYMPTOMS. SINCE 1994 EARLY CHILDHOOD SCHIZOPHRENIA IS DIAGNOSED AS AUTISM---THIS IS CAUSED BY OLDER FATHERS SPERM MAKING CELLS MUTATING ---THIS HAS BEEN OBSERVED SINCE 1958 AND SINCE 2001 MANY STUDIES FROM ALL AROUND THE WORLD HAVE CONFIRMED OLDER DAD AS A ROBUST CAUSAL FACTOR. OLDER DAD PAST 33 = MORE AUTISM GUARANTEED--REMEMBER VIRGINIA TECH AND YOU SEE AUTISM

Pittsburgh AUTISM SPEAKS "Walk Now for Autism"
The Pittsburgh AUTISM SPEAKS "Walk Now for Autism"


Thousands of individuals, families and friends whose lives are impacted by autism will join together to raise much-needed funds for critical scientific research and to increase awareness about a growing health crisis that now affects 1 in every 150 children at the 8th Annual Pittsburgh AUTISM SPEAKS “Walk Now for Autism” on Saturday, June 2, 2007 at Heinz Field.


Joining the walkers at this year’s event, sponsored by Toys “R” Us, will be special guests Larry Richert from KDKA News Radio 1020; Jake Ploeger, Channel 4 Action News Anchor and Mark Roithmayr, President of Autism Speaks.



Autism is a complex brain disorder that inhibits a person’s ability to communicate and develop social relationships, and is often accompanied by extreme behavioral challenges. One in 150 children is now diagnosed with an autism spectrum disorder, including one in 104 boys. Another child is diagnosed every 20 minutes.




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This newspaper is running this story over again to let people know!


ReutersIST(13/1/2007)


Chicago, September 04, 2006
First Published: 00:00



Children fathered by men at age 40 and older have a higher risk of developing autism, possibly because of mutations or other genetic changes, researchers reported on Monday.
The study "provides the first convincing evidence that advanced paternal age is a risk factor for autism spectrum disorder," said the authors from Mount Sinai School of Medicine, New York, and the Institute of Psychiatry, King's College London.

The findings were based on a look at thousands of children born in Israel during the 1980s. All males and three-fourths of the females born in the time period involved were checked by Israeli draft officials at age 17 and any psychiatric disorders were recorded.

"Offspring of men 40 years or older were 5.75 times more likely to have (autism disorders) compared with offspring of men younger than 30 years," said the study published in the Archives of General Psychiatry.

"Advancing maternal age showed no association," it added.

Autism can cause symptoms ranging from social isolation to repetitive and damaging behaviour and sometimes mental retardation.

The problem has become increasingly common, affecting 50 in every 10,000 children in the United States, in part due to greater awareness and changes in diagnoses, the study said.

The report said several genetic mechanisms might be behind the paternal age association found, including spontaneous mutations in sperm-producing cells.

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GIVE MONEY TO AUTISM, BUT NOT GIVE MONEY TO A PUBLIC HEALTH WARNING THAT OLDER FATHERING OF BABIES AND AUTISM GO HAND AND HAND- THAT COULD ACTUALLY HELP PREVENT SOME PATERNAL AGE DERIVED AUTISM WHICH IS THE CAUSE OF A CONSIDERABLE PORTION OF THE TOTAL

Philanthropy 2006

James. H. Simons

Amount Given or Pledged 2002-2006: $257 million
Causes: Math and science education, autism

Twenty-five years ago, top mathematician James H. Simons left a career in academia to start New York-based investment firm Renaissance Technologies. The 68-year-old money manager is now one of the richest men in the U.S.—and is fast becoming one of the nation’s top philanthropists. A former Harvard and MIT professor whose hedge fund thrives on algorithms and computers, Simons supports math and science initiatives in New York City, including his nonprofit, Math for America, and Stony Brook University, where he headed the math department for eight years. His private family foundation has assets worth half a billion dollars. In February, he committed $100 million to a study on autism, a disorder that affects his daughter. Since losing two adult sons in separate accidents 10 and three years ago, the family has maintained a 130-acre nature preserve on Long Island and built hospitals in Nepal in their memory.





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From Pharmalot


There’s nothing like a convention. And more than 15,000 doctors visited Washington, D.C. last week to attend Digestive Disease Week, the largest-ever gathering of gastrointestinal physicians. So Integrity in Science Watch paid a visit. Here’s the report.........................


The quietest space on the convention floor was the corner reserved for the small booths of patient advocacy groups, text book sellers, and scientific journals. ‘We don’t get any sponsorship from corporations for our meeting booths,’ says Crohn’s & Colitis Foundation of America rep Laura Hitchens, eyeing the towering Fuji stereo sound system blaring a description of a colonoscopy camera.

Thelma King Thiel of the Hepatitis Foundation says they wouldn’t say no if a company was to offer to fund their booths but, she adds, not many companies are interested in prevention.

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I WONDER WHAT THE AMERICAN MEDICAL ASSOCIATION'S VIEW IS ON WARNING THE PUBLIC THAT THERE IS A MALE BIOLOGICAL CLOCK AND THAT ADVANCING PATERNAL AGE AND AUTISM ETC. ARE CLOSELY RELATED. OF COURSE FERTILITY DOCS WOULD NOT SUPPORT THAT NEWS NOR WOULD MOST DOCS TREATING THE CHRONIC DISEASES WHICH WOULD NOT EXIST IN SUCH GREAT NUMBERS IF MEN KNEW TO FATHER THEIR BABIES IN THEIR MID 20S TO 32,33


ON THE AMA ON SERMO FROM PHARMALOT

The partnership was struck with a company called Sermo, which wants to use a web site to tap into the collective wisdom of its growing network of 15,000 U.S. docs. The two-year deal allows the AMA to survey its members on hot topics, just as Sermo’s Wall Street subscribers solicit docs’ opinions to help guide trading decisions on drug and device stocks.

But some docs are skeptical the service can advance medical safety, and PhRMA frets the service will spread as much rumor as fact. The AMA, however, hopes the deal will open a new line of communication, allowing its 250,000 docs to share everything from advice about treating a patient’s unique symptoms to opinions on whether the FDA should approve an experimental drug.

This does sound like a win-win, but there are potential problems. If creating an online community is so important, the AMA should do so. The organization shouldn’t, however, be in the business of promoting a forum - which allows anonymous postings - in hopes of enticing Wall Street firms willing to pay $100,000 to $500,000 for an online tip sheet.

This isn’t really about serving public health. This is exploiting the AMA membership in a way that cynically values the info exchanged as a high-priced commodity to be used to bolster the AMA’s bottom line. Exchanging medical info is laudable, but peddling the info in a way that may result in manipulation doesn’t build credibility.


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MORE AUTISM, CEREBRAL PALSY MENTAL RETARDATION IN IVF KIDS PATERNAL AGE IS A MAJOR RISK FACTOR FOR ALL OF THE ABOVE
Children born after IVF treatment 'face higher health risks'

Ian Sample in New Orleans
Thursday October 26, 2006
The Guardian


Children born to couples who have undergone fertility treatment are more likely to be diagnosed with autism, cancer and other disorders such as cerebral palsy and mental retardation, researchers claimed yesterday.
The higher risk to child health is believed to be caused by medical problems in the parents, such as diabetes and hypertension, damaging the child in the womb, but doctors conducting the study said IVF and other fertility treatments may also play a role. Medical records of children born after their parents sought fertility treatment showed they were four times more likely to have autism than those born to fertile parents. Childhood cancers including leukaemia and brain tumours also rose.

The risk of more minor problems, such as attention deficit hyperactivity disorder, rose by 40%, and other medical conditions affecting hearing and sight nearly doubled. Children had a 30% higher chance of being admitted to neonatal intensive care units and to stay in hospital for more than three days if they were born following fertility treatment, the study found.

The researchers stressed the figures represent relative risks. In July researchers at Guy's and St Thomas' hospital in London reported the prevalence of autism to be 0.39% in the general population, a figure that will include some children born to parents aided by fertility treatment. A fourfold rise in the risk of autism would see a child's chances of having the condition increase to 1.56%.

IS SEVERE AUTISM RELATED TO EARLY CHILDHOOD SCHIZOPHRENIA?

OBJECTIVE: Individuals with schizophrenia and their relatives tend to have either higher or lower than expected prevalences of autoimmune disorders, especially rheumatoid arthritis, celiac disease, autoimmune thyroid diseases, and type 1 diabetes. The purpose of the study was to estimate the association of schizophrenia with these disorders as well as a range of other autoimmune diseases in a single large epidemiologic study. METHOD: The Danish Psychiatric Register, the National Patient Register, and a register with socioeconomic information were linked to form a data file that included all 7,704 persons in Denmark diagnosed with schizophrenia from 1981 to 1998 and their parents along with a sample of matched comparison subjects and their parents. The data linkage required that the autoimmune disease occur before the diagnosis of schizophrenia. RESULTS: A history of any autoimmune disease was associated with a 45% increase in risk for schizophrenia. Nine autoimmune disorders had higher prevalence rates among patients with schizophrenia than among comparison subjects (crude incidence rate ratios ranging from 1.9 to 12.5), and 12 autoimmune diseases had higher prevalence rates among parents of schizophrenia patients than among parents of comparison subjects (adjusted incidence rate ratios ranging from 1.3 to 3.8). Thyrotoxicosis, celiac disease, acquired hemolytic anemia, interstitial cystitis, and Sjögren’s syndrome had higher prevalence rates among patients with schizophrenia than among comparison subjects and also among family members of schizophrenia patients than among family members of comparison subjects. CONCLUSIONS: Schizophrenia is associated with a larger range of autoimmune diseases than heretofore suspected. Future research on comorbidity has the potential to advance understanding of pathogenesis of both psychiatric and autoimmune disorders.

DO COPY NUMBER VARIATIONS FOUND IN SPORADIC AUTISM EXIST IN THE SPERMATAGONIA OF THE FATHERS? WILL ANYONE LOOK FOR THEM?

Jonathan Sebat and colleagues found the key to sporadic autism and it seems they will fail to follow up and look for the same CNVs in the father's sperm and spermatagonia. ESPECIALLY BE WARNED ABOUT AUTISM IF YOU HAVE AUTOIMMUNE DISORDERS OR YOUR CLOSE RELATIVES DO. DISEASE CAUSING MUTATIONS ACCUMULATE IN SPERM MAKING CELLS BETWEEN 33-35. YOUR RISK IS MUCH GREATER IF THERE IS ANY AUTISM OR OTHER BRAIN RELATED DISORDERS IN THE FAMILY. TRY TO FATHER YOUR BABIES BY 35-40 AT THE LATEST. IF YOU ARE ABLE TO AND YOUNGER THAN 35 CRYOPRESERVE YOUR SEMEN FOR ANY LATER FATHERING OF BABIES.

CANCERS, ALZHEIMER'S, AUTOIMMUNE DISEASES/ALL OF THEM, AUTISM, SCHIZOPHRENIA, AND MANY OTHER DISORDERS CAN BE CREATED DE NOVO IN OFFSPRING THROUGH SPONTANEOUS MUTATIONS IN SPERM MAKING CELLS. THESE MUTATIONS INCREASE WITH INCREASING PATERNAL AGE.



Finding the genes responsible for autism is one of the goals that Sebat and his colleagues have set for their next project. "We'll be screening at least 2,000 families over the next three years using a much higher resolution platform," Sebat said. He added that he hopes the data will provide a better estimate of the frequency of CNV in sporadic autism, as well as a view of a larger array of genes involved than when researchers restricted their studies to inherited cases. "I think this will be a study that really tips the balance in the field towards using technologies that can directly detect mutations, [and] focusing on the majority of cases that are sporadic."