Scientists To Discus Genetic Coding, Do All These Disorders Increase in Sporadic Cases, in Offspring of Older Fathers?

Local Scientists To Discus Genetic Coding
POSTED: 3:43 pm PDT June 9, 2007
UPDATED: 3:53 pm PDT June 9, 2007


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SAN DIEGO -- Scientists will meet in San Diego next week to compare notes on whether some particular human genes may be responsible for more than one type of disease.


Scientists have known for decades that genetic coding can make some people more likely to come down with particularly diseases, such as Tay-Sachs or sickle-cell anemia. The Federation of Clinical Immunology Societies next week will bring experts together to look into whether the same gene can cause widely differing types of hereditary illness.



Dr. Francis Collins of the National Human Genome Research Institute will present several studies about common gene abnormalities possibly linking inflammatory bowel disease, juvenile arthritis, multiple sclerosis, rheumatoid arthritis, systemic lupus and type 1 diabetes.


The meeting Monday will be at the Sheraton San Diego Resort & Marina.
POSTED: 3:43 pm PDT June 9, 2007
UPDATED: 3:53 pm PDT June 9, 2007

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Sign Up for Breaking News Alerts


SAN DIEGO -- Scientists will meet in San Diego next week to compare notes on whether some particular human genes may be responsible for more than one type of disease.


Scientists have known for decades that genetic coding can make some people more likely to come down with particularly diseases, such as Tay-Sachs or sickle-cell anemia. The Federation of Clinical Immunology Societies next week will bring experts together to look into whether the same gene can cause widely differing types of hereditary illness.



Dr. Francis Collins of the National Human Genome Research Institute will present several studies about common gene abnormalities possibly linking inflammatory bowel disease, juvenile arthritis, multiple sclerosis, rheumatoid arthritis, systemic lupus and type 1 diabetes.


The meeting Monday will be at the Sheraton San Diego Resort & Marina.

DO COPY NUMBER VARIATIONS FOUND IN SPORADIC AUTISM EXIST IN THE SPERMATAGONIA OF THE FATHERS? WILL ANYONE LOOK FOR THEM?

Jonathan Sebat and colleagues found the key to sporadic autism and it seems they will fail to follow up and look for the same CNVs in the father's sperm and spermatagonia. ESPECIALLY BE WARNED ABOUT AUTISM IF YOU HAVE AUTOIMMUNE DISORDERS OR YOUR CLOSE RELATIVES DO. DISEASE CAUSING MUTATIONS ACCUMULATE IN SPERM MAKING CELLS BETWEEN 33-35. YOUR RISK IS MUCH GREATER IF THERE IS ANY AUTISM OR OTHER BRAIN RELATED DISORDERS IN THE FAMILY. TRY TO FATHER YOUR BABIES BY 35-40 AT THE LATEST. IF YOU ARE ABLE TO AND YOUNGER THAN 35 CRYOPRESERVE YOUR SEMEN FOR ANY LATER FATHERING OF BABIES.

CANCERS, ALZHEIMER'S, AUTOIMMUNE DISEASES/ALL OF THEM, AUTISM, SCHIZOPHRENIA, AND MANY OTHER DISORDERS CAN BE CREATED DE NOVO IN OFFSPRING THROUGH SPONTANEOUS MUTATIONS IN SPERM MAKING CELLS. THESE MUTATIONS INCREASE WITH INCREASING PATERNAL AGE.



Finding the genes responsible for autism is one of the goals that Sebat and his colleagues have set for their next project. "We'll be screening at least 2,000 families over the next three years using a much higher resolution platform," Sebat said. He added that he hopes the data will provide a better estimate of the frequency of CNV in sporadic autism, as well as a view of a larger array of genes involved than when researchers restricted their studies to inherited cases. "I think this will be a study that really tips the balance in the field towards using technologies that can directly detect mutations, [and] focusing on the majority of cases that are sporadic."