Impact of age on male fertility.
University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, USA.
PURPOSE OF REVIEW:
increasing number of older men are seeking help for fathering a child,
but male fertility gradually declines with age. This review highlights
changes in male reproductive biology and practical clinical concerns for
Aging may have an impact on
sperm DNA damage such as single nucleotide polymorphisms. A recent
landmark study identified that the number of single gene de-novo
mutations in the offspring increased by two mutations per year based on
paternal age. Additionally, advanced paternal age has been linked with
neurocognitive disorders such as autism and schizophrenia. For the
management of hypogonadism, strategies using selective estrogen
modulators have been increasingly utilized to maintain fertility
Aging has an impact on male fertility potential, as well as potential genetic effects for the offspring.