"It is very possible that PATERNAL AGE is the major predictor of(non-familial) autism." Harry Fisch, M.D., author "The Male Biological Clock". Sperm DNA mutates and autism, schizophrenia bipolar etc. results. What is the connection with autoimmune disorders? Having Type 1 diabetes, SLE,etc. in the family, also if mother had older father. NW Cryobank will not accept a sperm donor past 35th BD to minimize genetic abnormalities.VACCINATIONS also cause autism.

Monday, February 02, 2009

Paternal age autism and other neurodevelopmental disorders due to older fathers can be prevented with education

Paternal age autism and other neurodevelopmental disorders due to older fathers can be prevented with education

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If autism, schizophrenia, and bipolar risk rises with the age of the father, why not let people know?
-... The Father Factor Scientific American Mind Feb

Best Answer - Chosen by Asker
Money. There is no profit in teaching people prevention. When these babies are born with problems, they need medication, which generates a profit.

That's why they have refined sugar and artificial sweeteners in so many kids foods and drinks. That's why there is aspartame in nearly every gum and mint and diet soda in existence. When kids start showing signs of ADD and other problems, like depression (which aspartame causes, too) they then provide a solution.
18 hours ago
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At 2:18 PM, Blogger Rich Murray said...

aspartame (methanol, formaldehyde, formic acid) toxicity research -- enough folic acid prevents harm: Rich Murray 2009.01.31

It is certain that high levels of aspartame use, above 2 liters daily
for months and years, must lead to chronic formaldehyde-formic acid

Fully 11 % of aspartame is methanol -- 1,120 mg aspartame in 2 liters diet soda, almost six 12-oz cans, gives 123 mg methanol (wood alcohol). The methanol is immediately released into the body after drinking .

Within hours, the liver turns much of the methanol into formaldehyde,
and then much of that into formic acid, both of which in time are
partially eliminated as carbon dioxide and water.

However, about 30 % of the methanol remains in the body as cumulative durable toxic metabolites of formaldehyde and formic acid -- 37 mg daily, a gram every month, accumulating in and affecting every tissue.

If only 10 % of the methanol is retained daily as formaldehyde, that would give 12 mg daily formaldehyde accumulation -- about 60 times more than the 0.2 mg from 10 % retention of the 2 mg EPA daily limit for formaldehyde in drinking water.

Bear in mind that the EPA limit for formaldehyde in drinking water is 1 ppm, or 2 mg daily for a typical daily consumption of 2 liters of water.......

cofactors re folic acid antagonist research include methanol (quickly turns into formaldehyde and then formic acid in humans) from tobacco and wood smoke, alcohol beverages, aspartame, demethylation of caffeine: Rich Murray 2008.12.01
Monday, December 1, 2008

Public release date: 1-Dec-2008
Contact: Kim Barnhardt
613-731-8610 x2224
Canadian Medical Association Journal

Maternal exposure to folic acid antagonists increases risks

Exposure to folic acid antagonists during pregnancy is associated with
a higher risk of placenta-mediated adverse outcomes such as
preeclampsia, placental abruption, fetal growth restriction or fetal
death reports a retrospective cohort study published in CMAJ .

Folic acid antagonists include a broad range of drugs used to treat
epilepsy, mood disorders, hypertension and infections. As
approximately 50% of pregnancies in industrialized countries like
Canada are unplanned, there is a risk of unintended exposure to these medications......

methanol impurity in alcohol drinks [ and aspartame ] is turned into neurotoxic formic acid, prevented by folic acid, re Fetal Alcohol Syndrome, BM Kapur, DC Lehotay, PL Carlen at U. Toronto,
Alc Clin Exp Res 2007 Dec. plain text: detailed biochemistry,
CL Nie et al. 2007.07.18: Murray 2008.02.24
Sunday, February 24, 2008

Alcoholism: Clinical and Experimental Research
Volume 31 Issue 12 Page 2114-2120, December 2007

Bhushan M. Kapur,;
Arthur C. Vandenbroucke, PhD, FCACB
Yana Adamchik,
Denis C. Lehotay,;
Peter L. Carlen;
(2007) Formic Acid, a Novel Metabolite of Chronic Ethanol Abuse, Causes Neurotoxicity, Which Is Prevented by Folic Acid
Alcoholism: Clinical and Experimental Research 31 (12), 2114-2120.


Methanol is endogenously formed in the brain and is present as a
congener in most alcoholic beverages.

Because ethanol is preferentially metabolized over methanol (MeOH) by
alcohol dehydrogenase, it is not surprising that MeOH accumulates in
the alcohol-abusing population.

This suggests that the alcohol-drinking population will have higher levels of MeOH's neurotoxic metabolite, formic acid (FA).

FA elimination is mediated by folic acid.

Neurotoxicity is a common result of chronic alcoholism.

This study shows for the first time that FA, found in chronic
alcoholics, is neurotoxic and this toxicity can be mitigated by folic acid administration.

To determine if FA levels are higher in the alcohol-drinking
population and to assess its neurotoxicity in organotypic hippocampal rat brain slice

Serum and CSF FA was measured in samples from both ethanol abusing and control patients, who presented to a hospital emergency department.
[ CSF = Cerebral Spinal Fluid ]

FA's neurotoxicity and its reversibility by folic acid were assessed using organotypic rat brain hippocampal slice cultures using clinically relevant concentrations.

Serum FA levels in the alcoholics (mean ± SE: 0.416 +- 0.093 mmol/l, n = 23) were significantly higher than in controls (mean ± SE: 0.154 +- 0.009 mmol/l, n = 82) (p < 0.0002).

FA was not detected in the controls' CSF (n = 20), whereas it was >0.15 mmol/l in CSF of 3 of the 4 alcoholic cases.

Low doses of FA from 1 to 5 mmol/l added for 24, 48 or 72 hours to the
rat brain slice cultures caused neuronal death as measured by propidium iodide staining.

When folic acid (1 umol/l) was added with the FA, neuronal death was prevented. [ umol = micromole ]

Formic acid may be a significant factor in the neurotoxicity of
ethanol abuse.

This neurotoxicity can be mitigated by folic acid administration at a clinically relevant dose.

Key Words:
Formic Acid, Folic Acid, Methanol, Neurotoxicity, Alcoholism......

"Of course, everyone chooses, as a natural priority, to enjoy peace,
joy, and love by helping to find, quickly share, and positively act
upon evidence about healthy and safe food, drink, and environment."

Rich Murray, MA Room For All
505-501-2298 1943 Otowi Road, Santa Fe, New Mexico 87505 new primary archive
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