"It is very possible that PATERNAL AGE is the major predictor of(non-familial) autism." Harry Fisch, M.D., author "The Male Biological Clock". Sperm DNA mutates and autism, schizophrenia bipolar etc. results. What is the connection with autoimmune disorders? Having Type 1 diabetes, SLE,etc. in the family, also if mother had older father. NW Cryobank will not accept a sperm donor past 35th BD to minimize genetic abnormalities.VACCINATIONS also cause autism.

Saturday, January 24, 2009

Paternal Ages Above and below 35 are associated with a different risk of schizophrenia

Paternal Age Above 35

Paternal Ages Above and below 35 are associated with a different risk of schizophrenia
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1: Eur Psychiatry. 2006 Dec 1; [Epub ahead of print] Links
Paternal ages below or above 35 years old are associated with a different risk of schizophrenia in the offspring.Wohl M, Gorwood P.
INSERM U675, 16 rue Henri Huchard 75018 Paris, France; AP-HP (Paris VII), C.H.U Louis Mourier, Service de psychiatrie du Professeur Ades, 178 rue des Renouillers, 92701 Colombes Cedex, France.

BACKGROUND: A link between older age of fatherhood and an increased risk of schizophrenia was detected in 1958. Since then, 10 studies attempted to replicate this result with different methods, on samples with different origins, using different age classes. Defining a cut-off at which the risk is significantly increased in the offspring could have an important impact on public health. METHODS: A meta-analysis (Meta Win((R))) was performed, assessing the mean effect size for each age class, taking into account the difference in age class references, and the study design. RESULTS: An increased risk is detected when paternal age is below 20 (compared to 20-24), over 35 (compared to below 35), 39 (compared to less than 30), and 54 years old (compared to less than 25). Interestingly, 35 years appears nevertheless to be the lowest cut-off where the OR is always above 1, whatever the age class reference, and the smallest value where offspring of fathers below or above this age have a significantly different risk of schizophrenia. CONCLUSION: No threshold can be precisely defined, but convergent elements indicate ages below or above 35 years. Using homogeneous age ranges in future studies could help to clarify a precise threshold.
Labels: older age of fatherhood, paternal age 35, Philip Gorwood, public health, schizophrenia



At 5:38 AM, Anonymous Andrew Lehman said...

Not exactly cooperating with Watson and Crick's "Central Dogma" there is the possibility that as a male grows older this testosterone levels go down influencing the maturation rate of his children.

This concept is the complimentary opposite of the Baron-Cohen thesis that as a mother gets older, her testosterone levels go up.


At 12:23 PM, Blogger Paul Raeburn said...

Here's a piece of mine (link below) on older fathers that you might be interested in, from the current issue of Scientific American Mind. Please feel to circulate as you see fit.
Paul Raeburn


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