"It is very possible that PATERNAL AGE is the major predictor of(non-familial) autism." Harry Fisch, M.D., author "The Male Biological Clock". Sperm DNA mutates and autism, schizophrenia bipolar etc. results. What is the connection with autoimmune disorders? Having Type 1 diabetes, SLE,etc. in the family, also if mother had older father. NW Cryobank will not accept a sperm donor past 35th BD to minimize genetic abnormalities.VACCINATIONS also cause autism.

Tuesday, September 11, 2007

Is the mutated gene due to paternal contribution ?

The Wellcome Trust does not mention whether paternal or maternal age is involved.

Mutations in the Insulin Gene Can Cause Neonatal Diabetes
Diabetes news • Sep 11, 2007
Ten previously unknown mMutations in the insulin gene can cause permanent neonatal diabetes, an unusual form of type 1 diabetes that affects very young children and results in lifelong dependence on insulin injections, report researchers from the University of Chicago and Peninsula University (Exeter, UK) in Sept. 18, 2007, issue of the Proceedings of the National Academy of Sciences, published early online.
Although abnormal insulin has been associated with milder cases of type 2 diabetes since the discovery of “insulin Chicago” in 1979, this is the first time that an insulin mutation has been connected to severe diabetes with onset early in life.type-1 diabetes.
The researchers describe the10 mutations, found in 221 patients from 16 families., and show how several of the mutations alter the way the protein folds, disrupting insulin synthesis. They suspect that the mutations alter the way insulin folds during its synthesis. TThey suggest that these improperly folded proteins interfere with other cellular processes in ways that eventually kill the cells that produce insulin.
“This is a novel and potentially treatable cause of diabetes in infants,” said study author Louis Philipson, MD, PhD, professor of medicine at the University of Chicago. “It’s exciting because each of these patients has one normal insulin gene as well as one mutated gene. If we could detect the disease early enough and somehow silence the abnormal gene, or just protect insulin-producing cells from the damage caused by misfolding, we might be able to preserve or restore the patient’s own insulin production.” .....

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