EFFECTS OF MALE AGE ON THE FREQUENCY OF GERMINAL AND HERITABLE CHROMOSOMAL ABNORMALITIES IN HUMANS AND IN RODENTS
: Fertil Steril. 2004 Apr;81(4):925-43. Links
Effects of male age on the frequencies of germinal and heritable chromosomal abnormalities in humans and rodents.Sloter E, Nath J, Eskenazi B, Wyrobek AJ.
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94550, USA.
OBJECTIVE: To review evidence regarding the effects of male age on germinal and heritable chromosomal abnormalities using available human and rodent studies and to evaluate possible underlying mechanisms. CONCLUSION(S): The weight of evidence suggests that the increasing trend toward fathering at older ages may have significant effects on the viability and genetic health of human pregnancies and offspring, primarily as a result of structural chromosomal aberrations in sperm.
PMID: 15066442 [PubMed - indexed for MEDLINE]
Labels: genetic health, older fathers, structural chromosomal aberrations in sperm
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