Am J Epidemiol. 2009 Nov 1;170(9):1118-26. Epub 2009 Sep 25.

Am J Epidemiol. 2009 Nov 1;170(9):1118-26. Epub 2009 Sep 25.

Risk of autism and increasing maternal and paternal age in a large north American population.
Grether JK, Anderson MC, Croen LA, Smith D, Windham GC.

Environmental Health Investigations Branch, California Department of Public Health, Richmond, California 94804, USA. judith.grether@cdph.ca.gov

Abstract
Previous studies are inconsistent regarding whether there are independent effects of maternal and paternal age on the risk of autism. Different biologic mechanisms are suggested by maternal and paternal age effects. The study population included all California singletons born in 1989-2002 (n = 7,550,026). Children with autism (n = 23,311) were identified through the California Department of Developmental Services and compared with the remainder of the study population, with parental ages and covariates obtained from birth certificates. Adjusted odds ratios and 95% confidence intervals were used to evaluate the risk of autism associated with increasing maternal and paternal age. In adjusted models that included age of the other parent and demographic covariates, a 10-year increase in maternal age was associated with a 38% increase in the odds ratio for autism (odds ratio = 1.38, 95% confidence interval: 1.32, 1.44), and a 10-year increase in paternal age was associated with a 22% increase (odds ratio = 1.22, 95% confidence interval: 1.18, 1.26). Maternal and paternal age effects were seen in subgroups defined by race/ethnicity and other covariates and were of greater magnitude among first-born compared with later-born children. Further studies are needed to help clarify the biologic mechanisms involved in the independent association of autism risk with increasing maternal and paternal age.

Blaylock: Big Pharma Vilified Researcher for Threatening Vaccine Program

Blaylock: Big Pharma Vilified Researcher for Threatening Vaccine Program

Thursday, January 13, 2011 10:52 AM

By Russell L. Blaylock, M.D.



Read more: Blaylock: Big Pharma Vilified Researcher for Threatening Vaccine Program

Delayed fathering and risk of mental disorders in adult offspring.

http://www.ncbi.nlm.nih.gov/pubmed/21220193

Early Hum Dev. 2011 Jan 8. [Epub ahead of print]

Delayed fathering and risk of mental disorders in adult offspring.
Krishnaswamy S, Subramaniam K, Ramachandran P, Indran T, Abdul Aziz J.

University of New England, Locked bag 4, NSW 2351, Australia.

Abstract
INTRODUCTION: Delayed parenting and child bearing at a very young age impose various risks to development of the offspring.

OBJECTIVE: This study aims to investigate the association between disparities in parental age and increased risk factor for common mental disorders in the progenies during adulthood.

METHODOLOGY: The Malaysian Mental Health Survey (MMHS) was analysed for this study. Respondents were asked to estimate the age of their parents at their birth. Presence of common mental disorders (CMD) was determined by referring to the diagnosis given by the Clinical Interview Schedule-Revised (CIS-R) instrument in the Programmed Questionnaire System (PROQSY) format. The association between parental age disparities and CMD was studied using logistic regression.

RESULT: Fifty three percent (n=1972) of the MMHS respondents (N=3666) knew the age of both parents and were included in the study. Three percent (n=53) had significant disparity in parental age, or a difference of 11years or more. Respondents born to parents with significant age disparity had a prevalence rate of 24% (95% CI=22.12-25.89) for CMD in comparison to 6% (95% CI=5.99-6.11) in their counterparts and 3.4 times higher risk for CMD, after adjusting for demographic factors, paternal age at birth and presence of family history of mental disorders. Amongst those born to older fathers aged 50 and above, the presence of disparity increased the rate for CMD to 42% (95% CI=39.82-44.18).

DISCUSSION: Disparity in parental age was significantly associated with increased risk for CMD. Various psychosocial factors contributing to age disparity in both the father and the mother could predispose to stress and mental health problems.

Copyright © 2010 Elsevier Ltd. All rights reserved.

keeping-anderson-cooper-honest-is-brian-deer-the-fraud

http://www.ageofautism.com/2011/01/keeping-anderson-cooper-honest-is-brian-deer-the-fraud.html

January 06, 201 1CryShame Response to BMJ Report Andrew Wakefield

January 06, 2011
CryShame Response to BMJ Report
From UK's CryShame:

PARENTS OF AUTISTIC CHILDREN SPEAK OUT AGAINST BMJ CLAIMS THAT WAKEFIELD 'S RESEARCH WAS FRAUDULENT HERE WE GO AGAIN.

Once again, the BMJ gives a platform for Brian Deer's investigation of the research behind Dr Andrew Wakefield at el's 1998 Lancet paper. This time the BMJ editors criticise all 13 co-authors for failing to check the data, warn all medical researchers and ethics committees to check carefully before they publish, and urge scrutiny of all Wakefield published papers (presumably all 100 plus papers). The BMJ allies itself with Deer's potentially defamatory attack on Wakefield.

Autism study doctor a 'victim of smear campaign' Andrew Wakefield

Autism study doctor a 'victim of smear campaign'