AUTISM PREVENTION FATHER BABIES 24-34 PATERNAL AGE IS KEY IN NON-FAMILIAL AUTISMVaccines

"It is very possible that PATERNAL AGE is the major predictor of(non-familial) autism." Harry Fisch, M.D., author "The Male Biological Clock". Sperm DNA mutates and autism, schizophrenia bipolar etc. results. What is the connection with autoimmune disorders? Having Type 1 diabetes, SLE,etc. in the family, also if mother had older father. NW Cryobank will not accept a sperm donor past 35th BD to minimize genetic abnormalities.VACCINATIONS also cause autism.

Thursday, December 31, 2009

Older fathers may cause autism and mental disorders

Older fathers may cause autism and mental disorders
December 31, 3:24 AMBirmingham Science News ExaminerPaul HamakerPrevious Comment Print



A British and United States study has produced the first study that "used an animal model to investigate the effects of advanced paternal age on behavioral deficits in the offspring."

The results indicate:
1) "In men, it is thought that the spermatogonial stem cell divisions occurring over the life-course of males result in higher mutational rates and cytogenetic abnormalities in the sperm of older men. Numerous neurological and psychiatric disorders have been related to genomic alterations."

2) "An alternative explanation is that epigenetic dysfunction underlies some paternal age effects. Epigenetic dysfunction has been associated with several neuropsychiatric disorders, including schizophrenia and bipolar disorder."

More simply put the older the father is the higher the potential for the children to have autism, schizophrenia and early-onset bipolar disorder.

This was a mouse study using C57BL/6J offspring. Young fathers were 2 months old. Old fathers were 10 months old. Using C57BL/6J (the most common reference inbred strain of mouse) reduces genetic variation.

The progeny of the older mice demonstrated less social and exploratory behaviors which are components of mental disorders exhibited in humans.

Advancing Paternal Age Is Associated with Deficits in Social and Exploratory Behaviors in the Offspring: A Mouse Model

Rebecca G. Smith1#, Rachel L. Kember1#, Jonathan Mill1, Cathy Fernandes2*, Leonard C. Schalkwyk1, Joseph D. Buxbaum3,4, Abraham Reichenberg1,3

1 Medical Research Council Social Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom, 2 Department of Psychological Medicine and Psychiatry, King's College London, London, United Kingdom, 3 Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America, 4 Laboratory of Molecular Neuropsychiatry, and the Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, New York, United States of America

Citation: Smith RG, Kember RL, Mill J, Fernandes C, Schalkwyk LC, et al. (2009) Advancing Paternal Age Is Associated with Deficits in Social and Exploratory Behaviors in the Offspring: A Mouse Model. PLoS ONE 4(12): e8456. doi:10.1371/journal.pone.0008456

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008456

Labels:

0 Comments:

Post a Comment

Links to this post:

Create a Link

<< Home

Top Autism Sites Health Blogs -  Blog Catalog Blog Directory StumbleUpon Toolbar Stumble It! http://www.stumbleupon.com/submit?url=http://www.yoursite.com/article.php&title=The+Article+Title blog directory PageRank Button Add to Technorati Favorites Health Blogs
Directory of Health Blogs Blogarama - The Blog Directory