Autism Doesn’t Have an Age Limit

Letters
Autism Doesn’t Have an Age Limit
May 30, 2009
To the Editor:

The Male Biological Clock - New Study Suggests Younger Men Produce Smarter Children


I've never heard of a male biological clock up until now but frankly it does make sense. I've always found it difficult to believe that a man in his fifties had the same "reproduction" capacity as a man in his twenties.

This concept isn't exactly new though, The New York Times wrote an article on the male biological clock in 2007 saying that studies showed older men produce children with higher rates of autism and schizophrenia.

Check out this CNN news video clip to find out more about the "male biological clock."

Video on the Male Biological Clock

I Doubt He Will Mention the Known Cause of Many Disorders- Paternal Age

Report: Collins to lead NIH


Posted by Bob Grant
[Entry posted at 26th May 2009 02:46 PM GMT]
View comments(4) | Comment on this news story

Francis Collins, the geneticist who led the Human Genome Project, is close to taking over the top spot at the National Institutes of Health, according to a report by Bloomberg News.

Collins, who was the director of the NIH's National Human Genome Research Institute from 1993 to 2008, is in the final stages of being screened by the administration of US President Barack Obama, an unnamed source told Bloomberg.

Flu Vaccinated Kids More Likely to Be Hospitalized

Flu Vaccinated Kids More Likely to Be Hospitalized
May 26th, 2009. By Evelyn Pringle
On May 19, 2009, researchers presented a study that found children who received the trivalent inactivated influenza vaccine [TIV] had a three times greater risk of hospitalization for the flu than kids who were not vaccinated at the International Conference of the American Thoracic Society in San Diego.

Growing Old With Autism

Op-Ed Contributor
Growing Old With Autism
KARL TARO GREENFELD
Published: May 23, 2009

M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age

J Autism Dev Disord. 2009 May 19. [Epub ahead of print] Links
Brief Report: Parental Age and the Sex Ratio in Autism.Anello A, Reichenberg A, Luo X, Schmeidler J, Hollander E, Smith CJ, Puleo CM, Kryzak LA, Silverman JM.
Harvard University, Cambridge, MA, USA.

The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.

Growing Old with Autism

Growing Old with Autism
By Karl Taro Greenfeld Monday, May. 25, 2009
Noah Greenfeld, 42, who spent 15 years in a state mental facility, is now in an assisted living home near his parents in Los Angeles.
Max S. Gerber for TIME
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Noah, my younger brother, does not talk. Nor can he dress himself, prepare a meal for himself or wipe himself. He is a 42-year-old man, balding, gaunt, angry and, literally, crazy. And having spent 15 years at the Fairview Developmental Center in Costa Mesa, Calif., a state facility, Noah has picked up the con's trick of lashing out before anyone could take a shot at him.

The Tip of the Legal Iceberg, Folks
May 14, 2009
Type size: - + Login or register to post comments Email Print RSS Feed Here's a lawsuit raising interesting questions in the field of personal genomics. Kamel at BayBlab talks about the case of a girl born with Fragile X syndrome who "is suing a sperm bank after genetic tests showed the genetic condition was carried on the father's X chromosome," he writes. "In this age of personal genomes and genetic testing, how much responsibility does a sperm bank have to screen for genetic disorders with every available test?" The outcome of the case will likely have direct legal consequences as genetic screening becomes more and more commonplace, he adds.

Men’s Biological Clocks. Will the Risks of Fathering a Baby After Age 35 Start A New Dating Trend?

May 4

Men’s Biological Clocks. Will the Risks of Fathering a Baby After Age 35 Start A New Dating Trend?

Posted by admin in POW WOW SHOW Topic, Your Guide To Healthy Relationships Today’s 50 may be yesterday’s 30 in some aspects of men’s aging, but medical studies reveal this isn’t true for a 50 year old’s sperm. Men are learning about about the genetic risks of fathering a baby after age 35. Will their newly-found biological clocks start a new dating trend?

What is a biological clock?

It commonly refers to the declining fertility, increasing risk for fetal birth defects, and altered hormone levels experienced by women as they age. Abundant scientific evidence now suggests that men also have a biological clock.

What are some risks of fathering a child after age 40?

A team of UK and US researchers recently reported that children born to men over 40 had a six times higher risk of autism than those born to men under 30.

Other studies have linked older fathers to an increased risk of miscarriages, and to children with bipolar disorder and the rare birth disorders like dwarfism.

Researchers at Columbia University College of Physicians and Surgeons found that men older than 40 were more than twice as likely to have a child who develops schizophrenia as men in their 20’s.

Why is older fatherhood a new cause for concern?

The theory linking paternal age with an offspring’s health rests on spontaneous mutations in the genes of a man’s sperm cells as he ages. New studies refute the earlier theory that men could father children into their old age with no ill effects.

What is the ideal age for men to father children?

To minimize genetic abnormalities, the American Society for Reproductive Medicine has set an upper age limit of 40 years old for semen donors, while UK fertility clinics only accept sperm donations from men aged 39 and under.

Studies suggest that to minimize the risk of autism, the paternal age should be under 32.

Could a man’s biological clock start a new dating trend?

A young man’s biological clock may encourage him seek a serious relationship with a young woman who is ready and willing to have children before he reaches the age of 35 or 40. These young men will have fewer years to date cougars.

A young woman who desires children may be less likely to date a father figure, unless he agrees to use a sperm donor if they decide to have children after his 50th birthday. Or she may simply prefer to date men under age 35 to increase the odds of having healthy babies with a mate closer to her age.

If more men and women over 40 spend less time dating younger, will they find unexpected delights in dating each other? Let us know if you notice these new trends in your dating life.

Dedicated to your relationship happiness,

Hadley

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The average age of American men marrying for the first time is now 28.

Say Yes. What Are You Waiting For?

By Mark Regnerus
Sunday, April 26, 2009

Spring is here, that glorious season when young men's fancies lightly turn to thoughts of love, as the poet Tennyson once suggested. "Lightly" is right.


Rebuttal: Real Wedding Bell Woes
For Better or Worse, Sooner Rather Than Later
The average age of American men marrying for the first time is now 28. That's up five full years since 1970 and the oldest average since the Census Bureau started keeping track. If men weren't pulling women along with them on this upward swing, I wouldn't be complaining. But women are now taking that first plunge into matrimony at an older age as well. The age gap between spouses is narrowing: Marrying men and women were separated by an average of more than four years in 1890 and about 2.5 years in 1960. Now that figure stands at less than two years. I used to think that only young men -- and a minority at that -- lamented marriage as the death of youth, freedom and their ability to do as they pleased. Now this idea is attracting women, too.


In my research on young adults' romantic relationships, many women report feeling peer pressure to avoid giving serious thought to marriage until they're at least in their late 20s. If you're seeking a mate in college, you're considered a pariah, someone after her "MRS degree." Actively considering marriage when you're 20 or 21 seems so sappy, so unsexy, so anachronistic. Those who do fear to admit it -- it's that scandalous.

How did we get here? The fault lies less with indecisive young people than it does with us, their parents. Our own ideas about marriage changed as we climbed toward career success. Many of us got our MBAs, JDs, MDs and PhDs. Now we advise our children to complete their education before even contemplating marriage, to launch their careers and become financially independent. We caution that depending on another person is weak and fragile. We don't want them to rush into a relationship. We won't help you with college tuition anymore, we threaten. Don't repeat our mistakes, we warn.

Sara, a 19-year-old college student from Dallas, equated thinking about marrying her boyfriend with staging a rebellion. Her parents "want my full attention on grades and school because they want me to get a good job," she told me. Understandable. But our children now sense that marrying young may be not simply foolish but also wrong and socially harmful. And yet today, as ever, marriage wisely entered into remains good for the economy and the community, good for one's personal well-being, good for wealth creation and, yes, good for the environment, too. We are sending mixed messages.

This is not just an economic problem. It's also a biological and emotional one. I realize that it's not cool to say that, but my job is to map trends, not to affirm them. Marriage will be there for men when they're ready. And most do get there. Eventually. But according to social psychologists Roy Baumeister and Kathleen Vohs, women's "market value" declines steadily as they age, while men's tends to rise in step with their growing resources (that is, money and maturation). Countless studies -- and endless anecdotes -- reinforce their conclusion. Meanwhile, women's fertility is more or less fixed, yet they largely suppress it during their 20s -- their most fertile years -- only to have to beg, pray, borrow and pay to reclaim it in their 30s and 40s. Although male fertility lives on, it doesn't hold out forever, either: Studies emerging from Europe and Australia note that a couple's chances of conceiving fall off notably when men pass the age of 40, and that several developmental disorders are slightly more common in children of older fathers.

Of course, there's at least one good statistical reason to urge people to wait on the wedding. Getting married at a young age remains the No. 1 predictor of divorce. So why on earth would I want to promote such a disastrous idea? For three good reasons:

First, what is considered "early marriage" by social scientists is commonly misunderstood by the public. The best evaluations of early marriage -- conducted by researchers at the University of Texas and Penn State University -- note that the age-divorce link is most prominent among teenagers (those who marry before age 20). Marriages that begin at age 20, 21 or 22 are not nearly so likely to end in divorce as many presume.