AUTISM PREVENTION FATHER BABIES 24-34 PATERNAL AGE IS KEY IN NON-FAMILIAL AUTISMVaccines

"It is very possible that PATERNAL AGE is the major predictor of(non-familial) autism." Harry Fisch, M.D., author "The Male Biological Clock". Sperm DNA mutates and autism, schizophrenia bipolar etc. results. What is the connection with autoimmune disorders? Having Type 1 diabetes, SLE,etc. in the family, also if mother had older father. NW Cryobank will not accept a sperm donor past 35th BD to minimize genetic abnormalities.VACCINATIONS also cause autism.

Thursday, December 25, 2008

The Paternal-Age Effect in Apert Syndrome Is Due, in Part, to the Increased Frequency of Mutations in Sperm

Copyright © 2003 The American Society of Human Genetics. All rights reserved.
The American Journal of Human Genetics, Volume 73, Issue 4, 939-947, 1 October 2003


doi:10.1086/378419

Report



The Paternal-Age Effect in Apert Syndrome Is Due, in Part, to the Increased Frequency of Mutations in Sperm

Rivka L. Glaser1, Karl W. Broman2, Rebecca L. Schulman1, Brenda Eskenazi3, Andrew J. Wyrobek4 and Ethylin Wang Jabs1, ,

1 Institute of Genetic Medicine, Center for Craniofacial Development and Disorders, Department of Pediatrics
2 Department of Biostatistics, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore
3 Division of Epidemiology, School of Public Health, University of California, Berkeley
4 Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA


Address for correspondence and reprints: Dr. Ethylin Wang Jabs, Institute of Genetic Medicine, Center for Craniofacial Development and Disorders, Department of Pediatrics, The Johns Hopkins School of Medicine, CMSC 1004, 600 North Wolfe Street, Baltimore, MD 21287-3914



Abstract
A paternal-age effect and the exclusive paternal origin of mutations have been reported in Apert syndrome (AS). As the incidence of sporadic AS births increases exponentially with paternal age, we hypothesized that the frequency of AS mutations in sperm would also increase. To determine the frequency of two common FGFR2 mutations in AS, we developed allele-specific peptide nucleic acid–PCR assays. Analyzing sperm DNA from 148 men, age 21–80 years, we showed that the number of sperm with mutations increased in the oldest age groups among men who did not have a child with AS. These older men were also more likely to have both mutations in their sperm. However, this age-related increase in mutation frequency was not sufficient to explain the AS-birth frequency. In contrast, the mutation frequency observed in men who were younger and had children with AS was significantly greater. In addition, our data suggest selection for sperm with specific mutations. Therefore, contributing factors to the paternal-age effect may include selection and a higher number of mutant sperm in a subset of men ascertained because they had a child with AS. No age-related increase in the frequency of these mutations was observed in leukocytes. Selection and/or quality-control mechanisms, including DNA repair and apoptosis, may contribute to the cell-type differences in mutation frequency

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