Sporadic Cases of Polycystic Kidney Disease due to germline mutations in older fathers

A tumor necrosis factor-[alpha]-mediated pathway promoting autosomal dominant polycystic kidney disease pp863 - 868
Polycystic kidney disease can be caused by germline mutations in the gene encoding PC2 followed by a second somatic 'hit' in the normal allele. Li and her colleagues now show that TNF-[alpha] can also act as a second hit and that disease progression can be blocked by anti-TNF-[alpha] treatment in an animal model.
Xiaogang Li et al.
doi:10.1038/nm1783
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emhl0Xztnp0HjT0B2UZ0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emhl0Xztnp0HjT0B2Ua0EK