establishing an association with rare copy number variants (CNV), which are over-represented in neurodevelopmental genes.

Copyright © 2008 Cell Press. All rights reserved.
Neuron, Vol 58, 165-167, 24 April 2008

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Schizophrenia: Genome, Interrupted
Rita M. Cantor1,2, and Daniel H. Geschwind1,2,3,
1 Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
2 Center for Neurobehavioral Genetics, Semel Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
3 Program in Neurogenetics, Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA


Corresponding author
Rita M. Cantor
rcantor@mednet.ucla.edu

Corresponding author
Daniel H. Geschwind
dhg@ucla.edu

Summary


Structural chromosomal variation is increasingly recognized as an important contributor to human diseases, particularly those of neurodevelopment, such as autism. A current paper makes a significant advance to schizophrenia genetics by establishing an association with rare copy number variants (CNV), which are over-represented in neurodevelopmental genes.