signaling pathway involving the D4 subtype of dopamine receptor that is linked to the risk of ADHD, autism, schizophrenia and Alzheimer�s disease.

Thursday, March 20, 2008
Richard Deth, PhD - Methionine Synthase A Methyl B12-Dependent Redox Sensor in Neuronal Cells


There is a connection between autism, schizophrenia and Alzheimer's disease


"Dr. Richard Deth is a molecular neuropharmacologist and Professor of Pharmacology and at Northeastern University in Boston. His research interests are directed toward elucidating the molecular events that cause neuropsychiatric disorders in which impaired attention is a prominent feature.

Dr. Deth�s laboratory has discovered a new signaling pathway involving the D4 subtype of dopamine receptor that is linked to the risk of ADHD, autism, schizophrenia and Alzheimer�s disease. A key aspect of his work is the role of folate-dependent methylation reactions, including their regulation by dopamine and growth factors and their inhibition by neurodevelopmental toxins.

Dr. Deth is the author of a recently published book entitled: "Molecular Origins of Human Attention: The Dopamine-Folate Connection"."

Source: http://www.podcast.azcast.net