AUTISM PREVENTION FATHER BABIES 24-34 PATERNAL AGE IS KEY IN NON-FAMILIAL AUTISMVaccines

"It is very possible that PATERNAL AGE is the major predictor of(non-familial) autism." Harry Fisch, M.D., author "The Male Biological Clock". Sperm DNA mutates and autism, schizophrenia bipolar etc. results. What is the connection with autoimmune disorders? Having Type 1 diabetes, SLE,etc. in the family, also if mother had older father. NW Cryobank will not accept a sperm donor past 35th BD to minimize genetic abnormalities.VACCINATIONS also cause autism.

Thursday, March 27, 2008

It’s possible that different combinations of these alterations produce different diseases, such as schizophrenia or the autism spectrum disorders,

From the Simons Foundation blog editor:


Cumulative effects
27 Mar 2008 4:33 PM It’s been clear for decades that there is no one gene that causes schizophrenia. Rather than being result of any one mutation, it turns out that schizophrenia is the unfortunate outcome of many different deletions and duplications that cause the developing brain to go awry.

This is most likely what’s going on in autism as well. In fact, as I wrote here a few weeks ago, the same deletions have been seen in both schizophrenia and autism.

As they are in people with autism, copy number variations — in which chunks of DNA are deleted or duplicated — are generally more common in those with schizophrenia, according to the report, published today in Science.

And variations that disrupt brain development are even more common: they’re seen in 15 percent of adult-onset schizophrenia and 20 percent of child- and adolescent-onset, compared with 5 percent of controls.

These variations are individually rare, and few of the mutations seen in the sample of 150 adults with schizoprehnia is repeated in more than one person or family. But together, their modest effects coalesce into a much larger syndrome.

Cumulative effects
27 Mar 2008 4:33 PM It’s been clear for decades that there is no one gene that causes schizophrenia. Rather than being result of any one mutation, it turns out that schizophrenia is the unfortunate outcome of many different deletions and duplications that cause the developing brain to go awry.

This is most likely what’s going on in autism as well. In fact, as I wrote here a few weeks ago, the same deletions have been seen in both schizophrenia and autism.

As they are in people with autism, copy number variations — in which chunks of DNA are deleted or duplicated — are generally more common in those with schizophrenia, according to the report, published today in Science.

And variations that disrupt brain development are even more common: they’re seen in 15 percent of adult-onset schizophrenia and 20 percent of child- and adolescent-onset, compared with 5 percent of controls.

These variations are individually rare, and few of the mutations seen in the sample of 150 adults with schizoprehnia is repeated in more than one person or family. But together, their modest effects coalesce into a much larger syndrome.

It’s possible that different combinations of these alterations produce different diseases, such as schizophrenia or the autism spectrum disorders, explaining why many of these diseases have so many features in common.

In this study, the researchers found copy number variations in genes important for the growth, survival and death of neurons. Glutamate and neuregulin, both of which have been implicated in schizophrenia and autism, are also in the list.
posted by ApoorvaMandavilli
Add Commentexplaining why many of these diseases have so many features in common.

In this study, the researchers found copy number variations in genes important for the growth, survival and death of neurons. Glutamate and neuregulin, both of which have been implicated in schizophrenia and autism, are also in the list.
posted by ApoorvaMandavilli
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