an affected first-born is seen most dramatically in the group of AGRE fathers who are 30–39 years
The paternal age distribution of the AGRE fathers, whose first child is autistic differs significantly from that of the 'control' sample (P=0.005). A 2 goodness-of-fit test with 2 degrees of freedom was conducted using percents in the 'control' group age categories to calculate the expected values in the AGRE sample. The shift toward higher paternal ages in those with an affected first-born is seen most dramatically in the group of AGRE fathers who are 30–39 years inclusive, which is 54.7% of the distribution compared with the 41.9 % that is expected. We interpret this shifted age distribution to provide support for the recently reported finding by Reichenberg and co-workers that autism risk is associated with advancing paternal age.
1: Mol Psychiatry. 2007 May;12(5):419-21. Links
Paternal age and autism are associated in a family-based sample.Cantor RM, Yoon JL, Furr J, Lajonchere CM.
PMID: 17453057 [PubMed - indexed for MEDLINE]
Labels: an affected first-born is seen most dramatically in the group of AGRE fathers who are 30–39 years
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