MANY RESEARCHERS HAVE TRIED TO WARN THE PUBLIC ABOUT PATERNAL AGE CREATING DELETERIOUS MUTATIONS FOR OFFSPRING THE MEDIA HAS BEEN IGNORING THEM

By age 45 and up Red flags should go up about the dangers to many offspring because the odds of neurocognitive damage which become significant at paternal age 35 are far greater and increase with paternal age.


The assertion that researchers do not know the cause of spontaneous mutations which are also called sporadic or germ line or de novo or non-familial mutations is erroneous. By the paternal age of 45 offspring are 500 to 800% more likely to be autistic or schizophrenic or have other de novo genetic disorder too numerous to name. The autism/Asperger's/schizophrenia/type 1 diabetes epidemics are not like lightening strikes at all. Why do the researchers like Michael Wigler, Jonathan Sebat etc. play dumb about spontaneous mutations and paternal age?

James F. Crow: He concluded that many diseases caused by mutations in offspring were the result of fertile old men. His rationale was that the gametes of older men had gone through more cell divisions. More cell divisions mean more mutations since it increases the chance that there is a mistake whenever the genome divides. For women, it's different. By the time a female is born, all the eggs that she will ever produce during her lifetime are already present in the ovary.

"The human mutation rate for base substitutions is much higher in males than in females and increases with paternal age." "I conclude that for a number of diseases the mutation rate increases with age at much faster rate than linear. This suggests that the greatest mutational hazard in the human population at present is fertile old males."http://www.pnas.org/cgi/content/full/94/16/8380

Warnings that autoimmune disorders and autism and schizophrenia are related beginning in the 1970s and since then from many researchers.

"Increased prevalence of familial autoimmune disease is a common finding among probands with various autoimmune disorders. Autistic disorder (autism) is a highly genetic disorder with known immune and immunogenetic abnormalities. Previous research has found an increased frequency of autoimmune disorders in families with autistic probands."

End fathering before 34 for the Health of Future Generations , Leslie B. Raschka, M.D.

"All genetic illnesses have their origin in a distant or recent mutation. Paternal age is an important determinant of mutation frequency in new germ cell mutation, causing both autosomal dominant and X-linked recessive illnesses. The role of other mutagenic factors is not the subject of this study. The results of my own research are supported by other information which indicates that the leading cause of genetic illness present in human populations is the ageing process in the male. Conceiving children by men younger than 35 years of age would prevent many genetic illnesses in future generations."

"The optimal time for a man to father a healthy child is the same as for a woman — 25 or so," says Dolores Malaspina, a psychiatry professor at New York University and coauthor of the study.

More on spontaneous/germ line/sporadic/de novo/non-familial mutations and genetic disorders:


Another of her studies found that fathers of sporadic schizophrenia cases were 5 years older than familial case fathers. If sporadic schizophrenia can originate from new mutations, then neurodevelopmental genes are reasonable candidates. Her study will examine if patients with sporadic schizophrenia, particularly those with fathers older than 35 at birth, show features found in other neurodevelopmental diseases that correlate with paternal age, such as craniofacial abnormalities, nonspecific cognitive deficits and delayed developmental milestones

Spain 1988


This suggests that a public health campaign to reduce older maternal age distribution in Spain may also lead to a reduction in dominant mutations and emphasizes the potential that a direct campaign for fathers to complete their
families before age 35 years may have a small, but measurable, effect in the primary prevention of dominant mutations.




Public Health Advisory suggested because it has been shown in ten studies since 1958 older fathers and schizophrenia are related. An analysis of many studies has shown that paternal age 35 and above is related to significantly more
schizophrenia







Most of our
donors are either currently involved with, or have finished
their higher education at the time of their participation in
our donor program. All donors are between 18 and 35
years of age in order to minimize genetic abnormalities.


1981
"Thus, it is good public health policy to recommend that both men and women complete their family a before age 40, if possible" ~
JM Friedman in an article called Genetic disease in the offspring of older fathers. Obstetrics & Gynecology 1981:57 745-749

Genetic disease in the offspring of older fathers
JM Friedman

Michael Craig Miller, M.D.

Mental Health Letter editor

"But we now know that the father's age also adds to the risk of potentially devastating diseases. And there is no practical way to detect these illnesses during pregnancy. For those weighing the risks, the decision can be wrenching. Adoption and in some instances a sperm donation may be acceptable alternatives to older fathers wanting to build a healthy family."


"Although boys were more likely to develop autism than girls, the risk for girls also increased as fathers got older. When fathers were young, about 1 in 6 children with autism were girls. After fathers passed the 40 year-old mark, the proportion of girls with autism rose to about 1 in 3. This suggests that the genetic factors in play for offspring of older fathers are different from those for offspring of younger fathers."




Michael Craig Miller, M.D. is Editor in Chief of the Harvard Mental Health Letter. He is also associate physician at Beth Israel Deaconess Medical Center and assistant professor at Harvard Medical School. He has been practicing psychiatry for more than 25 years and teaches in the Harvard Longwood Psychiatry Residency Program
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There is much, much more research to show that increasing paternal age in the last 25 or so years has lead to the vastly increased number of people with neurocognitive disorders now called autism and autoimmune disorders such as type 1 diabetes. This is apart from the role of the vaccination program in these and other disorders.



1: Hum Reprod. 1989 Oct;4(7):794-7. Links
Paternal age and mental functions of progeny in man.Auroux MR, Mayaux MJ, Guihard-Moscato ML, Fromantin M, Barthe J, Schwartz D.
Biologie de la Reproduction et du Développement, CHU Bicêtre, Le Kremlin-Bicêtre, France.


Study shows that genetic qualityof sperm deteriorates as men age


Understanding the effects of paternal age has become more important as increasing numbers of men are having children at older ages. Since 1980 there has been about a 40 percent increase in 35- to 49-year-old men fathering children, and a 20 percent decrease in fathers under 30.