'THERE IS NO EVIDENCE THAT THE RISK OF A DE NOVO CNV IS RELATED TO THE AGE OF EITHER PARENT"
~ARTHUR L. BEAUDET
THIS IS INTRIGUING, IS THERE EVIDENCE THAT DE NOVO CNVs ARE NOT RELATED TO AGE?
Scientists are not sure why the copy variations emerge, but it probably has something to do with the shuffling of genetic material that occurs in the production of eggs and sperm; the process is prone to errors.
"De novo point mutations in such genes could explain the advanced paternal age association that has been reported for autism13. There is no evidence, however, that the risk of a de novo CNV is related to the age of either parent."
There are several CNVs are associated with 17 conditions of the nervous system including Parkinsons and Alzheimer's disease. Sebat and Wigler et al. have found them in sporadic autism. Also there are CNVs involved in the genes that are involved with the immune system and in human evolution.
Labels: CNVs, eggs, shuffling of genetic material in the production of eggs and sperm, spermatogonia
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