AUTISM PREVENTION FATHER BABIES 24-34 PATERNAL AGE IS KEY IN NON-FAMILIAL AUTISMVaccines

"It is very possible that PATERNAL AGE is the major predictor of(non-familial) autism." Harry Fisch, M.D., author "The Male Biological Clock". Sperm DNA mutates and autism, schizophrenia bipolar etc. results. What is the connection with autoimmune disorders? Having Type 1 diabetes, SLE,etc. in the family, also if mother had older father. NW Cryobank will not accept a sperm donor past 35th BD to minimize genetic abnormalities.VACCINATIONS also cause autism.

Thursday, May 24, 2007

Advanced Paternal Age was noted for the fathers of patients with Crouzon or Pfeiffer Syndrome 34.50 +/- 7.65 years

OUR RESULTS SUGGEST THAT OLDER FATHERS HAVE ACCUMULATED OR ARE MORE SUSCEPTIBLE TO A VARIETY OF GERM LINE MUTATIONS


Published by the University of Chicago Press

--------------------------------------------------------------------------------
Title Paternal Origin of FGFR2 Mutations in Sporadic Cases of Crouzon Syndrome and Pfeiffer Syndrome
Author(s) Rivka L. Glaser, Wen Jiang, Simeon A. Boyadjiev, Alissa K. Tran, Andrea A. Zachary, Lionel Van Maldergem, David Johnson, Sinead Walsh, Michael Oldridge, Steven A. Wall, Andrew O. M. Wilkie, and Ethylin Wang Jabs
Identifiers The American Journal of Human Genetics, volume 66 (2000), pages 768–777
DOI: 10.1086/302831
PubMed ID: 10712195

Availability This site: PS | HTML | PDF (303.3k)
Copyright © 2000, The American Society of Human Genetics.
Abstract Crouzon syndrome and Pfeiffer syndrome are both autosomal dominant craniosynostotic disorders that can be caused by mutations in the fibroblast growth factor receptor 2 (FGFR2) gene. To determine the parental origin of these FGFR2 mutations, the amplification refractory mutation system (ARMS) was used. ARMS PCR primers were developed to recognize polymorphisms that could distinguish maternal and paternal alleles. A total of 4,374 bases between introns IIIa and 11 of the FGFR2 gene were sequenced and were assayed by heteroduplex analysis, to identify polymorphisms. Two polymorphisms (1333TA/TATA and 2710 C/T) were found and were used with two previously described polymorphisms, to screen a total of 41 families. Twenty-two of these families were shown to be informative (11 for Crouzon syndrome and 11 for Pfeiffer syndrome). Eleven different mutations in the 22 families were detected by either restriction digest or allele-specific oligonucleotide hybridization of ARMS PCR products. We molecularly proved the origin of these different mutations to be paternal for all informative cases analyzed (P=2.4×10-7; 95% confidence limits 87%100%). Advanced paternal age was noted for the fathers of patients with Crouzon syndrome or Pfeiffer syndrome, compared with the fathers of control individuals (34.50±7.65 years vs. 30.45±1.28 years, P<.01). Our data on advanced paternal age corroborates and extends previous clinical evidence based on statistical analyses as well as additional reports of advanced paternal age associated with paternal origin of three sporadic mutations causing Apert syndrome (FGFR2) and achondroplasia (FGFR3). Our results suggest that older men either have accumulated or are more susceptible to a variety of germline mutations.

Labels: , ,

0 Comments:

Post a Comment

<< Home

Top Autism Sites Health Blogs -  Blog Catalog Blog Directory StumbleUpon Toolbar Stumble It! http://www.stumbleupon.com/submit?url=http://www.yoursite.com/article.php&title=The+Article+Title blog directory PageRank Button Add to Technorati Favorites Health Blogs
Directory of Health Blogs Blogarama - The Blog Directory