WHY IS DIABETES TYPE 1 INCIDENCE RISING 3% EVERY YEAR?

PEDIATRICS Vol. 112 No. 5 November 2003, pp. e420-e420


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From the paper sited in the prior post

Increased Prevalence of Familial Autoimmunity in Probands With Pervasive Developmental Disorders
Thayne L. Sweeten, PhD*, Suzanne L. Bowyer, MD, David J. Posey, MD*, Gary M. Halberstadt, DO and Christopher J. McDougle, MD*

* Departments of Psychiatry
Pediatrics, Indiana University School of Medicine, and James Whitcomb Riley Hospital for Children Indianapolis, Indiana
St Vincent Hospital, Indianapolis, Indiana

"Finally, much attention has been focused lately on a possible increase in the incidence of autism.34 If this is the case, then the rise would coincide with recent increases in the incidence of type 1 diabetes in children reported by some investigators.35"




1: J Pediatr Endocrinol Metab. 2000 Apr;13(4):363-72. Related Articles, Links
The rising incidence of childhood type 1 diabetes in New South Wales, Australia.

Craig ME, Howard NJ, Silink M, Chan A.

Ray Williams Institute of Paediatric Endocrinology, Diabetes and Metabolism, Royal Alexandra Hospital for Children, Sydney, NSW, Australia.

OBJECTIVES: 1. To determine the incidence of type 1 (insulin dependent) diabetes in children aged 0-14 years who were resident in the state of New South Wales, Australia over the period 1992-1996. 2. To analyse the trends in incidence over the period 1990-1996. METHODS: Primary ascertainment of patients was performed using a prospective incidence register established in 1990. The secondary source of ascertainment was the National Diabetes Supply Scheme, a government subsidised scheme for diabetic supplies. RESULTS: There were 1,230 patients identified over the five-year period. Using the capture-recapture method, ascertainment was estimated to be 99% complete. The lowest incidence occurred in 1992 (16.9 per 10(5) person years) and the highest incidence was in 1995 (21.7 per 10(5)). The crude incidence of IDDM from 1990-1996 was 17.8 per 10(5) and there was a statistically significant rise in the incidence of type 1 diabetes over this period (p=0.0003). The annual incidence has increased on average by 3.2% per year since 1990. CONCLUSION: The incidence of childhood type 1 diabetes in NSW has increased significantly since 1990.



Increasing Incidence of Type 1 Diabetes in 0- to 17-Year-Old Colorado Youth
Kendra Vehik, MPH1, Richard F. Hamman, MD, DRPH1, Dennis Lezotte, PHD1, Jill M. Norris, MPH, PHD1, Georgeanna Klingensmith, MD1,2, Clifford Bloch, MD1,3, Marian Rewers, MD, PHD1,2 and Dana Dabelea, MD, PHD1
1 University of Colorado School of Medicine, Denver, Colorado
2 Barbara Davis Center, Aurora, Colorado
3 Pediatric Endocrine Associates, Greenwood Village, Colorado

Address correspondence and reprint requests to Dana Dabelea, MD, PHD, UCHSC, Campus Box B119, Denver, CO 80262. E-mail: dana.dabelea@uchsc.edu
RESULTS—The incidence of type 1 diabetes was 14.8 (95% CI 14.0–15.6) in 1978–1988 and 23.9 (22.2–25.6) in 2002–2004 for the state of Colorado (P < 0.0001). From 1978 to 2004, the incidence of type 1 diabetes increased by 2.3% (1.6–3.1) per year (P < 0.0001). The increase in incidence was significant for both non-Hispanic white (2.7% [95% CI 1.9–3.6] per year, P < 0.0001) and Hispanic youth (1.6% [0.2–3.1] per year, P = 0.013).

CONCLUSIONS—The incidence of type 1 diabetes has increased 1.6-fold among Colorado youth from 1978–1988 to 2002–2004, and both non-Hispanic white and Hispanic youth are affected by this trend.

Type 1 diabetes: pathogenesis and prevention
Kathleen Gillespie
Kathleen Gillespie is a lecturer with the Department of Clinical Science at North Bristol, University of Bristol, UK.


CMAJ • July 18, 2006; 175 (2). doi:10.1503/cmaj.060244.
© 2006 CMA Media Inc. or its licensors




Correspondence to: Dr. Kathleen M. Gillespie, Medical School Unit, Southmead Hospital, Bristol BS10 5NB, UK; fax +44 117 959 5336; k.m.gillespie@bristol.ac.uk


The current global increase in incidence of 3% per year is well reported,2 and it is predicted that the incidence of type 1 diabetes will be 40% higher in 2010 than in 1