Link between older age of fatherhood and an increased risk of schizophrenia was detected in 1958. Since then, 10 studies

We have to mourn all the lost lives from the ramage of Cho Seung-Hui.


What can cause such a being who could take the lives of so many?

What can be done to prevent more school shootings?


It isn't that we don't know, it really isn't such a mystery. For Some reason we are not told and we think that science does not know the answer, but it does know where autism and schizophrenia comes from. WHY WE ARE NOT TOLD IS ANOTHER STORY

Here one of 10 studies that all show the same results.

Am J Psychiatry 159:1528-1533, September 2002
© 2002 American Psychiatric Association

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Alan S. Brown, M.D., Catherine A. Schaefer, Ph.D., Richard J. Wyatt, M.D., Melissa D. Begg, Sc.D., Raymond Goetz, Ph.D., Michaeline A. Bresnahan, Ph.D., Jill Harkavy-Friedman, Ph.D., Jack M. Gorman, M.D., Dolores Malaspina, M.D. and Ezra S. Susser, M.D., Dr.P.H. <
Paternal Age as a Categorical Variable
Having demonstrated a positive association between risk of schizophrenia spectrum disorders and increasing paternal age on a continuous scale, we then examined the effect of paternal age on schizophrenia spectrum disorders risk using the aforementioned 10-year age categories. The unadjusted rate ratios for each of these categories, relative to the 15–24-year age group, are presented in Table 2. There was a steady, monotonic increase in the rate of schizophrenia spectrum disorders with advancing categories of paternal age. The monotonic increase in risk of schizophrenia spectrum disorders with advancing paternal age categories was similar when adjustment was made for maternal age only, and for maternal age, paternal education, paternal race, and parity.Paternal Age as a Categorical Variable
Having demonstrated a positive association between risk of schizophrenia spectrum disorders and increasing paternal age on a continuous scale, we then examined the effect of paternal age on schizophrenia spectrum disorders risk using the aforementioned 10-year age categories. The unadjusted rate ratios for each of these categories, relative to the 15–24-year age group, are presented in Table 2. There was a steady, monotonic increase in the rate of schizophrenia spectrum disorders with advancing categories of paternal age. The monotonic increase in risk of schizophrenia spectrum disorders with advancing paternal age categories was similar when adjustment was made for maternal age only, and for maternal age, paternal education, paternal race, and parity.

We have demonstrated a significant, dose-dependent association between advancing paternal age and risk of schizophrenia and other schizophrenia spectrum disorders in a prospective birth cohort study with several methodologic advantages compared with previous work. The findings persisted after adjustment for maternal age and were present when schizophrenia was examined separately from schizophrenia spectrum disorders. De novo mutations in the male germ cell line may be responsible, at least in part, for the observed association. While further work is necessary to confirm this interpretation, our study nonetheless provides further evidence that advanced paternal age is a risk factor for schizophrenia spectrum disorders. If the de novo mutation hypothesis can be confirmed by future studies, this discovery may lead to the identification of candidate genes for this disorder.