Healthier Babies - Damage to fathers' germ cells, or mutations, are responsible for some part of such unfavourable outcomes of pregnancy.
The publications on this website were written by Margaret and Arthur Wynn,
THE AGEING OF FATHERS
In the 1950s Penrose of University College, London (1955), studied the ages of the parents of babies with birth defects believed to have been caused by gene mutations. He concluded:
"The influence of the father's age is shown to he of critical significance. When the effect of the father's age on incidence is appreciable, as in achondroplasia, the hypothesis of fresh gene mutation as the cause is strengthened."
9. Conclusions
THE IMPORTANCE OF THE PROSPECTIVE FATHER
1. The time is ripe for greater attention to fathers' contribution to the outcome of pregnancy. This study suggests that fathers share responsibility with mothers for miscarriage, perinatal death and congenital malformations. Damage to fathers' germ cells, or mutations, are responsible for some part of such unfavourable outcomes of pregnancy.
Labels: Damage to father's germ cells, de novo mutations, influence of the father's age of critical importance
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